Biochemical and biophysical research communicationsHumansAortic Valve StenosisCoronary Artery DiseaseBiomarkersProteomics
Identification of key diagnostic and prognostic biomarkers for aortic valve stenosis with coronary artery disease through immunological profiling integrating proteomics, single-cell sequencing, and machine learning.
Yi Fang, Haining Wang, Yiming Li, Xiaojie Zhao, Bin Wang, Geng Wang, Dan Liu, Chenghui Yan, Kai Xu, Yaling Han
Published: 202510.1016/j.bbrc.2025.152855
Abstract
BACKGROUND: Aortic valve stenosis with coronary artery disease (AS-CAD) represents a common yet complex cardiovascular comorbidity, characterized by multifactorial pathogenesis and a lack of specific serum biomarkers. These limitations hinder early d…
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