Biochemical and biophysical research communicationsStomach NeoplasmsHumansPeritoneal NeoplasmsCancer-Associated FibroblastsSingle-Cell Analysis
Integrated bulk and single-cell RNA profiling implicates MFAP5+ CAFs in potential role in peritoneal metastasis of gastric cancer.
Ruiwen Ruan, Xiaofeng Dai, Lili Zhang, Jianping Xiong, Yangyang Yao, Jun Deng
Published: 202510.1016/j.bbrc.2025.152841
Abstract
Peritoneal metastasis (PM) is a lethal complication of advanced gastric cancer (GC), yet the stromal microenvironment driving PM remains incompletely understood. Using single-cell RNA sequencing, we profiled the stromal landscape of paired primary GC…
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