Biochemical and biophysical research communicationsHumansHepatoblastomaLiver NeoplasmsInduced Pluripotent Stem CellsUp-Regulation
PAGE4, upregulated in a novel iPSC-derived hepatoblastoma model, promotes hepatoblastoma progression.
Issei Kawakita, Shohei Honda, Yuta Yamada, Shugo Tanaka, Yuko Katayama, Takeshi Shionoiri, Asuka Ishii, Hiroyuki Kurosu, Kazuya Hamada, Kentaro Kumagai, Kensuke Nakazono, Rino Saito, Chihiro Terasaka, Ryo Takahashi, Insu Kawahara
Published: 202510.1016/j.bbrc.2025.152824
Abstract
Hepatoblastoma is a primary malignant liver tumor in children, thought to arise from abnormal liver development during the fetal period. Approximately 90 % of cases harbor activating mutations in CTNNB1, which encodes β-catenin, while other genetic m…
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