Biochemical and biophysical research communicationsAnimalsMiceTetraploidyProtein Serine-Threonine KinasesYAP-Signaling Proteins
Total cell number influences the timing of Hippo/YAP activation during preimplantation development in mouse tetraploid embryos.
Kaoru Fujino, Hiroyuki Imai, Sumito Matsuya, Ken Takeshi Kusakabe, Kiyoshi Kano
Published: 202510.1016/j.bbrc.2025.152811
Abstract
Total cell number may determine the timing of Hippo/YAP activity during first lineage specification. We combined mouse tetraploid embryos (reduced cell numbers) with a 2 × 4n aggregation approach (increasing cell numbers) to test whether YAP nuclear…
Preview only. Read the full abstract at the source