Biochemical and biophysical research communicationsHumansDihydroorotaseOrotic AcidEnzyme InhibitorsDihydroorotate Dehydrogenase
Structural basis of potent inhibition of the human CAD dihydroorotase domain by 5-aminoorotic acid.
Yen-Hua Huang, Tsai-Ying Huang, Man-Cheng Wang, Cheng-Yang Huang
Published: 202510.1016/j.bbrc.2025.152804
Abstract
Dihydroorotase (DHOase) catalyzes the reversible conversion of N-carbamoyl-L-aspartate to dihydroorotate in de novo pyrimidine biosynthesis. In humans, DHOase (huDHOase) is part of the CAD enzyme complex and contains a flexible loop that alternates b…
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