Biochemical and biophysical research communicationsAnimalsHeart FailureMiceInbred C57BLStroke Volume
Mild transverse aortic constriction and continuous aldosterone administration induce heart failure with preserved ejection fraction.
Shinsuke Hanatani, Naoya Nakashima, Fumihiko Ogata, Masahiro Yamamoto, Yuki Okuno, Toshihiro Yamada, Satoru Yamamura, Satoshi Araki, Yuichiro Arima, Eiichiro Yamamoto, Yasuhiro Izumiya, Kenichi Tsujita
Published: 202510.1016/j.bbrc.2025.152802
Abstract
The mechanisms of heart failure with preserved ejection fraction (HFpEF) remain poorly understood, partly due to the lack of reliable animal models. We aimed to establish a more adaptable HFpEF model by focusing on pressure overload-induced hypertrop…
Preview only. Read the full abstract at the source