Biochemical and biophysical research communicationsMatrix Metalloproteinase 2HumansCyclin-Dependent Kinase Inhibitor p21Neoplasm InvasivenessSelenium-Binding Proteins
Selenium-binding protein 1 suppresses tumor invasion by destabilizing MMP2 mRNA through a p21-dependent AUF1-ARE regulatory axis.
Yulei Wang, Wenhang Lin, Yixuan Liao, Guochun Zhang
Published: 202510.1016/j.bbrc.2025.152794
Abstract
Selenium-binding protein 1 (SELENBP1) is frequently downregulated across multiple human solid tumors and has long been recognized as a tumor suppressor. Our previous work established that SELENBP1 restrained cell-cycle progression by transcriptionall…
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