Biochemical and biophysical research communicationsAnimalsc-Mer Tyrosine KinaseHeart FailureMacrophagesMyocytes
Macrophage Mertk mediates pressure overload-induced heart failure via type I interferon response.
Yikai Cui, Liwei Liu, Jinyan Zhang, Xiaoyi Zou, Gangze Li, Hao Jiang, Zhifeng Yao, Junbo Ge
Published: 202510.1016/j.bbrc.2025.152767
Abstract
Macrophages play a critical role in the pathogenesis and progression of heart failure, wherein sustained cardiomyocyte apoptosis is a key feature. The MER proto-oncogene tyrosine kinase (MERTK) is a critical receptor that mediates the efferocytosis o…
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