Biochemical and biophysical research communicationsAnimalsOrexinsMiceInbred C57BLWakefulness
Sleep-promoting effects of preproorexin C-terminal peptide in mice.
Kosuke Honda, Hiroshi Tsuneki, Hisakatsu Ito, Kenji Mori, Morikatsu Yoshida, Tsutomu Wada, Toshiyasu Sasaoka
Published: 202510.1016/j.bbrc.2025.152760
Abstract
The hypothalamic orexin system plays an essential role in the stabilization of sleep and wakefulness. Orexin A and orexin B, a pair of neuropeptides derived from a common precursor protein, preproorexin, promote wakefulness. However, the functional r…
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