Behavioural brain researchAnimalsBrain-Derived Neurotrophic FactorAlzheimer DiseaseMicrogliaMale
TLR4 inhibition attenuates facilitatory effects of JQ1 on learning & memory via polarization of microglia, and BDNF expression in Alzheimer's disease model.
Saba Ahangaran, Arash Pourgholaminejad, Rahim Nosrati, Parvin Babaei
Published: 202610.1016/j.bbr.2025.115919
Abstract
OBJECTIVE: Neuroinflammation is a core event in the pathogenesis of Alzheimer's disease (AD), which is mediated by microglia. The present study aimed to investigate the effect of co-inhibition of Toll-like receptor (TLR4) and chromatin reader of BRD4…
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