Brain, behavior, and immunity
Higher CSF sTREM2 is related to slower hippocampal atrophy and cognitive decline independently of pTau181 levels.
Henry Gilreath Stephenson, Tobey J Betthauser, Erin Jonaitis, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Michael Ewers, Jannis Denecke, Tyler K Ulland, Nathaniel A Chin, Ozioma C Okonkwo, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Kaj Blennow
Published: 202610.1016/j.bbi.2026.106468
Abstract
Heightened TREM2-dependent microglial activation is thought to protect against the negative effects of Alzheimer's disease (AD) neuropathology, but data in preclinical disease and in the context of aging are lacking. This study examined the associati…
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