Brain, behavior, and immunity
Astrocytic FKBP5 regulates neuroinflammation and cognitive outcomes in male mouse models of excitotoxic epilepsy.
Yu-Ling Gan, Shang-Hsuan Lin, Yu-Ping Kang, Jia-Zhen Zhou, Wei-Hsuan Huang, Ping-Hua Sung, Chia-Chi Hung, Pei-Chien Hsu, Shu-Yin Chu, Feng-Shiun Shie, I-Hui Lee, Chung-Jiuan Jeng, Yi-Hsuan Lee
Published: 202610.1016/j.bbi.2026.106278
Abstract
FK506-binding protein 51 (FKBP51, encoded by FKBP5) is a multisignaling cochaperone that regulates cellular stress responses and inflammatory signaling through the NF-κB pathway. Although FKBP51 is upregulated in reactive astrocytes, its role in epil…
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