Brain, behavior, and immunity
Acute peripheral versus central inhibition of insulin receptors differentially alters cytokine and blood-brain barrier responses to an inflammatory stimulus.
Tanmai Bandarupalli, Cassidy Noonan, Kim Hansen, Riley Weaver, Kristen Baumann, William A Banks, Michelle A Erickson, Elizabeth M Rhea
Published: 202510.1016/j.bbi.2025.106251
Abstract
The blood-brain barrier (BBB)'s role in protecting the brain from exposure to harmful circulating factors has led to its disruption being implicated in neurodegenerative diseases such as vascular dementia and Alzheimer's disease. Insulin resistance,…
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