Biochimica et biophysica acta. Reviews on cancerHumansrac1 GTP-Binding ProteinBiological ProductsPancreatic NeoplasmsAnimals
Advancement in preclinical development of cancer treatment agents through modulation of Rac1: From EHop-016 to natural products.
Yingyi Liu, Sze-Nga Wong, Aiping Lyu, Joshua Ka-Shun Ko
Published: 202610.1016/j.bbcan.2025.189522
Abstract
Rac1 belongs to the Rac subfamily under the Rho family of GTPases. As an effector of K-Ras protein encoded by the KRAS gene, Rac1 activation plays a key role in KRAS-driven cancer development and is largely involved in the promotion of cell migration…
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