Biochimica et biophysica acta. Reviews on cancerHumansLiver NeoplasmsCarcinomaHepatocellularTumor Microenvironment
Fibrosis-driven hepatocarcinogenesis, metastasis and immune evasion: Mechanisms and therapeutic targets.
Zilong Zhang, Xiaoping Chen, Bixiang Zhang, Wanguang Zhang, Ze-Yang Ding, Expert Group on Portal Hypertension of the Chinese College of Surgeons (CCS), Chinese Medical Doctor Association (CMDA)
Published: 202610.1016/j.bbcan.2025.189517
Abstract
Hepatocellular carcinoma (HCC) arising on a background of fibrosis has fundamental mechanistic and clinical differences compared to HCC that arises in a non-fibrotic liver. The fibrotic microenvironment is characterized by extracellular matrix (ECM)…
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