Biochimica et biophysica acta. Reviews on cancerHumansCheckpoint Kinase 1NeoplasmsProtein-Tyrosine KinasesCell Cycle Proteins
Revisiting CHK1 and WEE1 kinases as therapeutic targets in cancer.
Nehal Arvind Kumar, P Manasa, Jaikanth Chandrasekaran
Published: 202510.1016/j.bbcan.2025.189482
Abstract
Uncontrolled cell division is a defining characteristic of cancer, driven by genomic instability. This instability disrupts the DNA damage response network, exacerbates replication stress, and impairs cell cycle checkpoints. Although conventional DNA…
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