Biochimica et biophysica acta. Proteins and proteomicsCryoelectron MicroscopyAmyloidProtein Conformationbeta-StrandModels
Direct cryo-EM visualization of the β-sheet structure in curved amyloid protofibril.
Naoki Yamamoto, Jin Inoue, Ritsumi Saito, Kei Nanatani, Ai Takahashi, Seizo Koshiba, Ryo Kanno
Published: 202610.1016/j.bbapap.2025.141105
Abstract
Protofibrils are key intermediates to explore effective therapeutic strategies for amyloid-related diseases; however, their structural features remain largely ambiguous. Here, we report a direct visualization of the intermolecular β-sheet structure o…
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