Biochimica et biophysica acta. BiomembranesDimethyl SulfoxideLipid BilayersCryoprotective AgentsMolecular Dynamics SimulationSolvents
Reassessing DMSO-lipid interactions: Improved AMBER force fields emphasize solvent rather than bilayer effects in cryoprotection.
Ivan Klbik, Milan Melicherčík, Dušan Račko, Igor Maťko, Ján Lakota, Ondrej Šauša
Published: 202610.1016/j.bbamem.2025.184481
Abstract
The interaction of dimethyl sulfoxide (DMSO) with lipid membranes has been extensively studied using molecular dynamics (MD) simulations, yet discrepancies with experimental findings persist. Here, we re-evaluate the effects of low DMSO concentration…
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