Biochimica et biophysica acta. BiomembranesTrypanosoma cruziAcetophenonesTrypanocidal AgentsAnimalsBaccharis
Exploring the antitrypanosomal activity of viscidone, an acetophenone derivative from Baccharis retusa (Asteraceae), using biomembrane models.
Eric Umehara, Carlos Henrique T Dos Santos, Laura F da Silva, Fernanda Thevenard, André G Tempone, Matheus E Rosa, Luciano Caseli, João Henrique G Lago
Published: 202610.1016/j.bbamem.2025.184477
Abstract
This study evaluated the antiprotozoal activity of viscidone, an acetophenone isolated from Baccharis retusa, against trypomastigote forms of Trypanosoma cruzi. Viscidone showed potent antiparasitic effects (EC₅₀ = 21.3 ± 1.4 μM), comparable to benzn…
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