Biochimica et biophysica acta. BiomembranesSpike GlycoproteinCoronavirusSARS-CoV-2HumansMolecular Dynamics Simulation
Immune antibodies recognizing the stem region of SARS-CoV-2 spike protein: Molecular modeling and in vitro study of synthetic peptides presentation to the antibodies.
Elena T Aliper, Ivan M Ryzhov, Polina S Obukhova, Alexander B Tuzikov, Oxana E Galanina, Marina M Ziganshina, Gennady T Sukhikh, Nikolay A Krylov, Stephen M Henry, Roman G Efremov, Nicolai V Bovin
Published: 202610.1016/j.bbamem.2025.184472
Abstract
Antibodies to peptide 1147 (amino acids 1147-61) of the SARS-CoV-2 S protein are highly diagnostic. Peptide 1147, although located in a region that is partly spatially hidden in the intact protein, is not subject to mutations, suggesting therapeutic…
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