Biochimica et biophysica acta. Molecular cell research
ATM kinase phosphorylates HSP90 on T297 changing its conformation dynamics and promoting its interaction with HER2 receptor tyrosine kinase.
Giulia Fianco, Irene Taddei, Veronica Oropallo, Claudia Contadini, Alessandra Ferri, Laura Coculo, Stefano A Serapian, Giorgio Colombo, Venturina Stagni, Daniela Barilà
Published: 202610.1016/j.bbamcr.2026.120110
Abstract
Heat Shock Protein 90 (HSP90) is an essential molecular chaperone whose activity is regulated not only by co-chaperones but also by distinct post-translational modifications. Interestingly, its chaperone activity is essential for the stability of sev…
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