Biochimica et biophysica acta. Molecular cell researchMelanomaHumansSTAT3 Transcription FactorDrug ResistanceNeoplasm
Sustained Galiellalactone treatment breaks the metastatic resilience of BRAF-inhibitor-resistant melanoma cells.
Sujoy Bhowmik, Saumya Ranjan Badajena, Satyajit Laxman Murkute, Dumarapu Bhagyalaxmi, Purusottam Mohapatra
Published: 202610.1016/j.bbamcr.2025.120096
Abstract
STAT3 hyperactivation in metastatic and therapy-resistant melanoma drives tumorigenesis and immunotherapy resistance by promoting tumor-stromal interactions, making its inhibition a crucial therapeutic strategy. Interestingly, synthetic STAT3 inhibit…
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