Biochimica et biophysica acta. Molecular cell researchAnimalsCisplatinAcute Kidney InjuryTumor Necrosis Factor-alphaMice
SPRED2 controls the severity of cisplatin-induced acute kidney injury by inhibiting ERK activation and TNFα production in mice.
Xu Yang, Jiali He, Tong Gao, Masayoshi Fujisawa, Toshiaki Ohara, Steven L Kunkel, Teizo Yoshimura, Akihiro Matsukawa
Published: 202610.1016/j.bbamcr.2025.120091
Abstract
Cisplatin is an effective chemotherapeutic agent used to treat solid tumors, but its clinical use is limited by acute kidney injury (AKI), in which ERK signaling plays a crucial role. Here, we investigated whether Sprouty-related EVH1 domain-containi…
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