Biochimica et biophysica acta. Molecular cell researchHumansOxaliplatinCell MovementColorectal NeoplasmsTumor Suppressor Protein p53
Hotspot mutant p53-R273H enhances mitochondrial biogenesis and cell migration in primary colorectal cancer in response to oxaliplatin.
Toni Martinez-Bernabe, Pere Miquel Morla-Barcelo, Alessandra Fiore, Massimo Donadelli, Pilar Roca, Jordi Oliver, Jorge Sastre-Serra, Daniel G Pons
Published: 202610.1016/j.bbamcr.2025.120073
Abstract
Oxaliplatin is commonly known as a successful chemotherapy for advanced colorectal cancer, improving patient survival and eradicating micro-metastases, but its use in early stages remains controversial. Mitochondria fuel energy-intensive programs suc…
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