Biochimica et biophysica acta. Molecular and cell biology of lipidsInositolSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiaeValproic AcidPhosphatidic Acids
Valproate causes inositol depletion in yeast by decreasing levels of phosphatidic acid and increasing Opi1-mediated repression of INO1 expression.
Chisom J Onu, Michael Adu, Gil-Soo Han, George M Carman, Miriam L Greenberg
Published: 202610.1016/j.bbalip.2026.159717
Abstract
Valproic acid (VPA) is a widely prescribed mood stabilizer used in the pharmacological management of bipolar disorder (BD), a psychiatric illness that affects 2% of the world's population. Although VPA has been in use for four decades, the therapeuti…
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