Biochimica et biophysica acta. Molecular and cell biology of lipidsHumansFemalePregnancyFerroptosisCholestasis
ACADVL upregulation is associated with placental ferroptosis in intrahepatic cholestasis of pregnancy.
Mi Tang, Jianghui Cai, Ling Zhang, Liling Xiong, Xuejia Gong, Jinzhu Fu, Peilin Wang, Mengqiu Luo, Hong Liu, Ying Ye, Min Yu, Heng Yu, ShaSha Xing, Xiao Yang
Published: 202610.1016/j.bbalip.2025.159711
Abstract
INTRODUCTION: Intrahepatic cholestasis of pregnancy (ICP) is a disorder characterized by maternal pruritus and elevated total bile acid concentrations during pregnancy, posing severe fetal risks associated with placental dysfunction. However, the mec…
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