Biochimica et biophysica acta. Gene regulatory mechanismsHumansNeoplasmsDNA MethylationEpigenesisGenetic
TET enzymes: Involvement in cancer development and therapeutical perspectives.
Tarik Aanniz, Meriem El Fessikh, Jihane Touhtouh, Sara Aboulaghras, Nasreddine El Omari, Asaad Khalid, Ashraf N Abdalla, Mohammed Amanullah, Bey Hing Goh, Learn-Han Lee, Abdelhakim Bouyahya
Published: 202510.1016/j.bbagrm.2025.195118
Abstract
The TET family of enzymes is essential for the dynamic regulation of DNA methylation and the epigenetic landscape of human genomes. Their ability to oxidize 5-methylcytosine (5mC) into various hydroxymethylated derivatives facilitates active DNA deme…
Preview only. Read the full abstract at the source