Biochimica et biophysica acta. General subjectsHumansAnimalsQuinolinesMiceDrug Resistance
Tetrahydroquinoline/4,5-dihydroisoxazoline derivatives counteract multidrug resistance in cancer cells by inhibiting P-glycoprotein (ABCB1)-mediated transport.
Marina Hembecker, Diogo Henrique Kita, Azam Rashidian, Luis C Vesga, Bruna Estelita Ruginsk, Arnold R Romero Bohórquez, Stelia Carolina Mendez-Sanchez, Vinicius Goncalves Maltarollo, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Antti Poso, Katalin Goda, Suresh V Ambudkar, Vivian Rotuno Moure, Thales Kronenberger
Published: 202610.1016/j.bbagen.2025.130894
Abstract
Cancer treatment is challenged by the emergence of multidrug resistance (MDR). MDR is often caused by the overexpression of certain ABC transporters, such as P-glycoprotein (P-gp, ABCB1) in the plasma membrane of tumor cells and tumor stem cells. Inh…
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