Biochimica et biophysica acta. General subjectsSpike GlycoproteinCoronavirusSARS-CoV-2Molecular Dynamics SimulationCOVID-19 Vaccines
Receptor binding domain of SARS CoV2 spike protein exhibits in vitro liquid-liquid phase separation due to structural disorderedness that may challenge the vaccine-generated antibody binding.
Manikanta Sodasani, Abhinav V K S Grandhi, Niharikha Mukala, Jahnavi Chintalapati, Madhuri Vissapragada, Madhumita Aggunna, Ravikiran S Yedidi
Published: 202610.1016/j.bbagen.2025.130889
Abstract
In this study we expressed, purified and demonstrated the protein liquid-liquid phase separation (LLPS) formation by the receptor binding domain (RBD) of coronavirus spike protein in vitro. Our molecular dynamics simulations revealed multiple structu…
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