Biochimica et biophysica acta. General subjectsHomocysteineDehydroascorbic AcidHumansNeuronsOxidation-Reduction
Structural characterization of a L-dehydroascorbic acid-L-homocysteine thiolactone reaction product: Intracellular formation in neuronal cells.
Ghizlane Loubane, Gabriel Robert, Syed Benazir Firdaus, Raphaël Robidas, Christian Comeau, Pierre-Luc Boudreault, Jeampy E Komba, Hugo Gagnon, J Richard Wagner, Stephen Naylor, Klaus Klarskov
Published: 202610.1016/j.bbagen.2025.130882
Abstract
Homocysteine thiolactone (HTL) has been implicated in cardiovascular and neurological pathologies. While homocysteine can S-homocysteinylate thiol groups in proteins, the chemical properties of HTL facilitates covalent binding to protein ε-amino grou…
Preview only. Read the full abstract at the source