Biochimica et biophysica acta. Molecular basis of disease
Osteopontin aggravates myocardial fibrosis by promoting phenotypic transition of cardiac fibroblasts via Hippo-YAP pathway.
Chen Liu, Wentao Liu, Yuan Wang, Chengzhi Jiang, Sheng Chen, Qianqian Huang, Xiaowei Xiong, Li Wang, Guohua Zeng, Qiren Huang
Published: 202510.1016/j.bbadis.2025.168150
Abstract
Osteopontin (OPN), a glycosylated protein ubiquitously in cellular matrix, exhibits a low expression in normal myocardial tissue but a high expression in fibrotic myocardial tissue. However, the action and mechanisms of OPN on the pathogenesis of myo…
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