Biochimica et biophysica acta. Molecular basis of disease
UBE2K promotes breast cancer growth by ubiquitinating and degrading STUB1 to regulate the PKA/CREB1 signaling pathway, forming a feedback loop.
Jiancheng Mou, Hongchao Tang, Xiaoge Hu, Zhuotao Yang, Haotian Su, Da Qian, Chenhong Li, Haotian Liu, Zhihao Ye, Mingxing Xu, Shuyan Liu, Qinghui Zheng, Xiaozhen Liu, Xin Zeng, Qiuran Xu
Published: 202510.1016/j.bbadis.2025.168145
Abstract
BACKGROUND: Breast cancer (BC) remains one of the major threats to women's health in the 21st century, due to its high incidence and mortality rates. Ubiquitin-conjugating enzymes, as members of the ubiquitin-proteasome system, are responsible for nu…
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