Biochimica et biophysica acta. Molecular basis of disease
HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis.
Yanan Zhang, Lei Li, Gaiqin Li, Junyuan Zhu, Zexue Qi, Chunqing Zhang
Published: 202510.1016/j.bbadis.2025.168140
Abstract
PURPOSE: We aimed to investigate the role and possible mechanism of action of hexokinase domain containing 1 (HKDC1) in liver cirrhosis. METHODS: Hepatic stellate cell (HSC) activation model was established in LX-2 cells by transforming growth factor…
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