Biochimica et biophysica acta. Molecular basis of disease
Vitamin D attenuates PCSK9-driven phenotypic switch of vascular smooth muscle cells and neointimal hyperplasia via SIRT6 activation.
Sushmitha Duddu, Yash T Katakia, Nivedha Suresh, Rituparna Chakrabarti, Syamantak Majumder, Praphulla Chandra Shukla
Published: 202510.1016/j.bbadis.2025.168135
Abstract
Pathologically activated vascular smooth muscle cells (VSMCs) upregulate proprotein convertase subtilisin/kexin type 9 (PCSK9), contributing to vascular inflammation and remodeling. Although both PCSK9 and 25-hydroxyvitamin D (25OHD), the active form…
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