Atherosclerosis
Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation.
Ya Li, Julian Leberzammer, Xavier Blanchet, Rundan Duan, Michael Lacy, Vasiliki Triantafyllidou, Veit Eckardt, Eva Briem, Anna Simone Jung, Rui Su, Joel Guerra, Yvonne Jansen, Michael Hristov, Wolfgang Enard, Jürgen Bernhagen
Published: 202510.1016/j.atherosclerosis.2025.120608
Abstract
BACKGROUND AND AIMS: Atherosclerosis is a chronic immunometabolic disease driven by lipid accumulation and immune cell infiltration. Macrophages and T cells play key roles throughout plaque development. Galectin-1 (Gal-1), a glycan-binding protein, m…
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