Ageing research reviews
The m⁶A epitranscriptome: A regulatory nexus linking cellular senescence and oncogenesis.
Yao Xu, Xin Zhou, Xiaoling Su, Wenxi Xie, Zhijie Huang, Shan Yu, Jinghua Tan, Jun He, Ji Zhang
Published: 202610.1016/j.arr.2026.103032
Abstract
N⁶-methyladenosine (m⁶A) orchestrates RNA fate decisions through a dynamic interplay of writers, erasers, and readers, modulating splicing, stability, and translation. This review unveils how m⁶A fine-tunes senescence-associated pathways (p53/p21, p1…
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