Ageing research reviews
Proteolysis-targeting chimera (PROTAC): a promising senolytic strategy.
Gang Fan, Qingping Zhang, Weiming Guo, Miao Liu, Dong Tan, Zhihan Tang, Jing Yang
Published: 202610.1016/j.arr.2026.103027
Abstract
Senescent cells (SCs) accumulate with aging and contribute to the development of age-related pathologies. These cells evade apoptosis through upregulation of senescent cell anti-apoptotic pathways (SCAPs), making their selective elimination, a strate…
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