Annals of the rheumatic diseases
Type I interferon endotypes drive divergent clinical trajectories in childhood-onset SLE uncovered through a novel systems immunology approach.
Heather Cross, Junjie Peng, Thomas McDonnell, Bethan Goulden, Faraan Cheema, Ashley Tan, Joseph Parker, Ruth Adeyeye, Stacy P Ardoin, Laura E Schanberg, Laura B Lewandowski, APPLE trial investigators and Childhood Arthritis and Rheumatology Research Alliance (CARRA), Coziana Ciurtin, George A Robinson
Published: 202610.1016/j.ard.2025.12.011
Abstract
OBJECTIVES: Childhood-onset systemic lupus erythematosus (cSLE) is a severe autoimmune disease with significant morbidity and enhanced type I interferon (IFN-I) signalling, potentially contributing to its aggressive clinical course. This study aimed…
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