Annals of the rheumatic diseases
Altered AP-1, RUNX, and EGR chromatin dynamics drive human fibrotic lung disease.
Eleanor Valenzi, Minxue Jia, Peter Gerges, Jingyu Fan, Tracy Tabib, Rithika Behera, Haiyi Mao, Dan Xue, Eun Mi Ju, Yuechen Zhou, John C Sembrat, Jishnu Das, Panayiotis V Benos, Harinder Singh, Robert Lafyatis
Published: 202510.1016/j.ard.2025.12.003
Abstract
OBJECTIVES: Pulmonary fibrosis can result from autoimmune, inflammatory, or idiopathic conditions, including systemic sclerosis-associated interstitial lung disease (SSc-ILD). Previous studies have implicated myofibroblasts and SPP1hi macrophages as…
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