Annals of the rheumatic diseases
Treatment nonresponders in lupus nephritis characteristically exhibit persistent type I interferon signalling in monocytes: a longitudinal single-cell transcriptomic analysis.
Woo-Joong Kim, Hye-Soon Lee, So-Young Bang, Young Bin Joo, Bo-Kyeong Kang, Mimi Kim, Hyunsung Kim, Sung Yul Park, Woong-Yang Park, Eui-Cheol Shin, Sang-Cheol Bae
Published: 202610.1016/j.ard.2025.12.002
Abstract
OBJECTIVES: We aimed to characterise the dynamic transcriptional changes associated with treatment responses in lupus nephritis (LN) through longitudinal single-cell RNA sequencing analysis of peripheral blood mononuclear cells (PBMCs) during standar…
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