Annals of the rheumatic diseases
RUNX1 is expressed in a subpopulation of dermal fibroblasts and is associated with disease severity of systemic sclerosis.
Rezvan Parvizi, Zhiyun Gong, Helen C Jarnagin, Diana M Toledo, Tamar R Abel, Dillon Popovich, Madeline J Morrisson, Tammara A Wood, Sasha Shenk, Mrinal K Sarkar, Olesya Plazyo, Poulami Dey, Anthony Coon, Jake M Erba, Lam C Tsoi
Published: 202510.1016/j.ard.2025.10.033
Abstract
OBJECTIVES: The activation of runt-related transcription factor 1 (RUNX1) in fibroblasts has been implicated in wound healing and fibrosis; however, the role of RUNX1 in the fibrotic progression of the autoimmune disease systemic sclerosis (SSc) rema…
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