Annals of the rheumatic diseases
A human-STING specific macrocyclic peptide suppresses cGAS-STING-induced inflammation.
Jian Zheng, Junjie Wu, Hang Yin, Zhiyue Zhang, Qifeng Zhao, Xiaoshen Wang, Xuzichao Li, Yang Liu, Youming Zhang, Zhi Yao, Heng Zhang, Yizhen Yin, Long Li
Published: 202510.1016/j.ard.2025.10.023
Abstract
Suppression of hyperactive stimulator of interferon genes (STING) may provide therapeutic benefits to treat inflammatory diseases. We identified a macrocyclic peptide, named P1, which binds to human STING (hSTING) by a new platform for the discovery…
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