Annals of the rheumatic diseasesHumansDermatomyositisProteasome Endopeptidase ComplexAnimalsMuscle Fibers
Enhanced proteasome activity in perifascicular myofibres is a hallmark of dermatomyositis and its inhibition is efficient in preclinical models.
Léa Debrut, Margherita Giannini, Giulia Quiring, Simone Perniola, Daniela Rovito, Céline Keime, Béatrice Lannes, Aleksandra Nadaj-Pakleza, Jean-Baptiste Chanson, Anne-Laure Charles, Bernard Geny, Daniel Metzger, Gilles Laverny, Alain Meyer
Published: 202510.1016/j.ard.2025.08.031
Abstract
OBJECTIVES: This study aims to characterise the molecular pathways underpinning perifascicular muscle fibre alterations to identify repositionable molecules for dermatomyositis (DM) treatment, and validate potential candidates in preclinical models.…
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