Antiviral research
Lapachol, a dihydroorotate dehydrogenase inhibitor, demonstrates antiviral activity against feline calicivirus in vitro and in vivo.
Zexin Liu, Guohong Wu, Jianwei Mao, Yutong Zheng, Qizhen Fu, Sifan Lin, Yizhou Chen, Weisan Chen, Pei Zhou, Jianxin Chen
Published: 202610.1016/j.antiviral.2026.106354
Abstract
Feline calicivirus (FCV) infection poses a significant threat to domestic cats, causing a spectrum of clinical symptoms ranging from mild respiratory issues to severe systemic diseases. Although FCV vaccines are available, their protective efficacy i…
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