Antiviral researchAntiviral AgentsAnimalsHumansCRISPR-Cas SystemsMice
Genetic determinants of efficacy of antiviral drugs revealed by genome-wide CRISPR screens.
Wei Jiang, Ailing Yang, Jingchuan Ma, Dawei Lv, Mingxian Liu, Chao Wang, Shuo Chen, Huiling Fang, Yankai Chu, Zhengjin He, Wenrui Li, Yucheng Liu, Yun Zhao, Zhaocai Zhou, Gang Long
Published: 202510.1016/j.antiviral.2025.106309
Abstract
Nucleoside and nucleobase analog antiviral drugs are pivotal in antiviral therapy, but comprehensive methods to understand their cellular response mechanisms and genetic regulators are still lacking. Here, we show that Eμ-Myc; Arf-/- mouse lymphoma c…
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