Antiviral researchAntiviral AgentsHumansHepatitis B virusAnimalsRNA
Small molecule HBV RNA destabilizing drugs: Drugs of the future or compounds from the past?
Timothy M Block, Dimitar Gotchev, Yanming Du
Published: 202510.1016/j.antiviral.2025.106288
Abstract
Small-molecule HBV RNA destabilizing agents, such as the dihydroquinolizinones (DHQs), were first disclosed in a patent filing in 2015 and in peer reviewed literature in 2018. These compounds inhibit Poly-adenylating Polymerases 5 and 7 (PAPD5/7) and…
Preview only. Read the full abstract at the source