Annals of diagnostic pathology
H3-3A gene mutation analysis in giant cell tumor of bone and its histologic mimics: A single institutional study from India.
Shantveer G Uppin, Monalisa Hui, Derin Mary Thomas, Megha S Uppin, Vinay Nalla, K Nageshwara Rao, Rajeev Reddy, Himakanth Lingala
Published: 202610.1016/j.anndiagpath.2026.152606
Abstract
Though the diagnostic utility of H3.3G34W immunohistochemistry (IHC) for giant cell tumor of bone (GCTB) is well established, it is limited by a proportion of cases with variant H3-3A mutations [H3-3A: c.104G>T p. Gly35Val (G34V), H3-3A: c.103G>A p.…
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