The American journal of pathology
Neonatal Thymic Dynamics Influence Autoimmune Pathology by Shaping the Suppressive Potential of Regulatory T Cells.
Shigefumi Matsuzawa, Aya Ushio, Kunihiro Otsuka, Ruka Nagao, Takaaki Tsunematsu, Masafumi Moriyama, Naozumi Ishimaru
Published: 202610.1016/j.ajpath.2025.12.007
Abstract
Neonatal thymectomy (TX) has been known to induce experimental autoimmune disease models in mice for over half a century. The thymic microenvironment, including thymic epithelial cells (TECs), plays a crucial role in establishing self-tolerance in T…
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