The American journal of pathologyAnimalsAcetaminophenHepatocytesChemical and Drug Induced Liver InjuryProto-Oncogene Proteins c-met
Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice.
Siddhi Jain, Ranjan Mukherjee, Gillian Williams, Jia-Jun Liu, Lanuza A P Faccioli, Zhiping Hu, Rodrigo M Florentino, George K Michalopoulos, Alejandro Soto-Gutierrez, Silvia Liu, Joseph Locker, Bharat Bhushan
Published: 202610.1016/j.ajpath.2025.09.010
Abstract
Despite the well-known role of MET in liver regeneration after partial hepatectomy, its role in the clinically relevant acetaminophen (APAP)-induced liver injury (AILI) model remains unexplored. AILI markedly differs from partial hepatectomy because…
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