Acta biomaterialia
M2 macrophage-derived exosome nanoplatform for targeted H2S delivery to alleviate hepatic ischemia-reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects.
Tianci Zuo, Chengge Shi, Jiayu Li, Diwei Li, Xiaoming Luo, Mengzhu Xu, Mingli Su, Hongyang Lu, Yanmei Zhang, Xiaowen Hu, Qiang Zhou, Quazi T H Shubhra, Xiaosong He, Xiaojun Cai
Published: 202510.1016/j.actbio.2025.12.041
Abstract
Hepatic ischemia-reperfusion injury (HIRI) presents a critical challenge in liver surgery, transplantation, and trauma, driven by the interplay of oxidative stress, inflammation, and ferroptosis. Current treatments are limited by poor targeting and i…
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